ea0029p1070 | Neuroendocrinology | ICEECE2012
Libri D.
, Bonomi M.
, Duminuco P.
, Guizzardi F.
, Gentilini D.
, Persani L.
Introduction: Idiopathic central hypogonadism (ICH) is a rare and heterogeneous disease due to defects of GnRH secretion or action. ICH could be associated or not with hypo-anosmia respectively identifying the Kallmanns syndrome (KS) or the normosmic ICH (nICH). Even though 14 disease genes have been identified, in 70% of patients no genetic cause could be identified, suggesting additional regulatory genes and still unknown mechanisms. Thus, with the aim to identify new ...